Zhejiang Industrial Invention Patent, named as a 3-benzoisoxazole-4-indole maleimide derivative and its use, application number is 21310083721.9. On September 2, 2014, the Patent Office received the first instance examination opinion, the examination opinion is that the patent has no authorized prospects, in the original agency can not handle the case, the inventor contacted me to entrust me. As a risk agent, after careful study, analysis and professional defense, we have been authorized by the Patent Office. The State Patent Office issued a notice of patent authorization for invention on August 3, 2015.